Beilstein J. Org. Chem.2015,11, 2334–2342, doi:10.3762/bjoc.11.254
aplysinin B (3), together with 15 known compounds (4–18) were isolated from the sponge Aplysinalacunosa collected from Stirrup Cay, Bahamas. The structures of the isolated compounds were identified on the basis of MS and NMR data analysis. The 13C NMR assignment of spirocyclohexadienylisoxazoline moieties
of 1 and 2 were confirmed by an 1,1-ADEQUATE experiment. Compounds 1 and 2 showed a mild to moderate cytotoxic activities against KB-31 and FS4-LTM cell lines. Only aplysinin A (2) exhibited cytotoxicity against MCF-7 cells.
Keywords: alkaloids; Aplysinalacunosa; bromotyrosine; marine natural
activities, including antiviral [2], antibiotic [3][4][5], Na+/K+ ATPase inhibition [6][7][8], anti-HIV [9][10], antifungal [11], histidine-H3 antagonist [12], cytotoxic [13][14], and antimalarial activities [15][16][17]. During our investigation of the chemical constituents of Aplysinalacunosa (Aplysinidae
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Graphical Abstract
Figure 1:
Three new bromotyrosine derivatives isolated from sponge Aplysina lacunosa: 14-debromo-11-deoxyfist...